Prolonged Noise Exposure Causes Increase In Inflammatory Signaling in Hypertensive Mice; FASEB Journal, April 2020.
Selected Excerpts
We have previously established development of hypertension and an increase in inflammatory parameters following acute noise exposure [Münzel et al. Eur Heart J 2017; Kröller-Schön et al. Eur Heart J 2018], a feature that was also observed in angiotensin II induced hypertension [Wenzel et al. Circulation 2011].
For the first time, we here aimed to characterize the effects of noise exposure and subsequent chronic stress in mice with pre-established hypertension in order to determine the degree of overlap in the mechanistic pathways. In order to accomplish this, we treated C57Bl/6J mice for 7 days with angiotensin II, aircraft noise, or both. A cumulative worsening was evident in the hypertension plus noise group over hypertensive-only and noise-only controls.